产品说明书
P62-mediated mitophagy inducer
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同义名 : | PMI |
| CAS号 : | 1809031-84-2 | |
| 货号 : | A780511 | |
| 分子式 : | C14H9IN4O2 | |
| 纯度 : | 98% | |
| 分子量 : | 392.151 | |
| MDL号 : | MFCD31620757 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 7 mg/mL(17.85 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | P62-mediated mitophagy inducer is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer does not recruit Parkin or collapse the mitochondrial membrane potential during activation of mitochondrial autophagy and remains active in cells that lack a well-functioning PINK1/ Parkin pathway[1].P62-mediated mitophagy inducer stabilizes Nrf2 at a concentration of 10 μM for 1, 3, 6, and 24 hours. At 9 hours, P62-mediated mitophagy inducer can upregulate the expression of P62 and activate mitophagy. At 24 hours, P62-mediated mitophagy inducer acts downstream of the PINK1/Parkin signaling pathway in MEFs[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.55mL 0.51mL 0.26mL |
12.75mL 2.55mL 1.28mL |
25.50mL 5.10mL 2.55mL |
| 参考文献 |
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