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GW791343 2HCl

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Chemical Structure| 1019779-04-4 同义名 : GW791343 dihydrochloride
CAS号 : 1019779-04-4
货号 : A776318
分子式 : C20H26Cl2F2N4O
纯度 : 98%
分子量 : 447.349
MDL号 : MFCD22689439
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(40.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(223.54 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 GW791343 dihydrochloride is a P2X7 allosteric modulator exhibiting species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.24mL

0.45mL

0.22mL

11.18mL

2.24mL

1.12mL

22.35mL

4.47mL

2.24mL
参考文献

[1]Felix RA, Martin S, et al. Development of a comprehensive set of P2 receptor pharmacological research compounds. Purinergic Signal. 2012 Feb;8(Suppl 1):101-12.

[2]Michel AD, Clay WC, et al. Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects. Br J Pharmacol. 2008 Nov;155(5):738-51.