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Brincidofovir

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Chemical Structure| 444805-28-1 同义名 : Cmx001;hexadecyloxypropyl-CDV;HDP (S)-HPMPC;HDP-CDV;1-O-hexadecyloxypropyl Cidofovir
CAS号 : 444805-28-1
货号 : A762325
分子式 : C27H52N3O7P
纯度 : 99%
分子量 : 561.692
MDL号 : MFCD09970716
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 CMX001 was developed as an orally active, lipophilic form of cidofovir (CDV) and has enhanced activity in vitro and in vivo compared to CDV against certain herpesviruses, adenoviruses and orthopoxviruses.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.78mL

0.36mL

0.18mL

8.90mL

1.78mL

0.89mL

17.80mL

3.56mL

1.78mL
参考文献

[1]Quenelle DC, Lampert B, et al. Efficacy of CMX001 against herpes simplex virus infections in mice and correlations with drug distribution studies. J Infect Dis. 2010 Nov 15;202(10):1492-9.

[2]Parker S, Touchette E, et al. Efficacy of therapeutic intervention with an oral ether-lipid analogue of cidofovir (CMX001) in a lethal mousepox model. Antiviral Res. 2008 Jan;77(1):39-49.