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MI-2-2

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Chemical Structure| 1454920-20-7 同义名 : -
CAS号 : 1454920-20-7
货号 : A761249
分子式 : C17H20F3N5S2
纯度 : 98%
分子量 : 415.499
MDL号 : MFCD29044864
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(252.71 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 MI-2-2 is a potent inhibitor of menin-MLL. MI-2-2 binds to menin with a Kd value of 22 nM and is very effective in disrupting the bivalent protein-protein interactions between menin and MLL. MI-2-2 exhibits a very pronounced specific activity against MLL leukaemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression and differentiation[1].MI-2-2 inhibits both the interaction of menin with MBM1 (IC50=46 nM) and with the bivalent fragment of MLL consisting of MBM1 and MBM2 (IC50=520 nM). In BMC transformed with MLL-AF9 and in the human leukaemia cell line MV4;11 carrying the MLL-AF4 translocation, MI-2-2 showed very pronounced activity at low micromolar concentrations[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.41mL

0.48mL

0.24mL

12.03mL

2.41mL

1.20mL

24.07mL

4.81mL

2.41mL
参考文献

[1]Shi A, et al. Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood. 2012;120(23):4461-4469.