产品说明书

Pristimerin

Print
Chemical Structure| 1258-84-0 同义名 : Celastrol methyl ester;NSC 99281;UNII-28ZK7PR57S;Celastrol-methylether
CAS号 : 1258-84-0
货号 : A759879
分子式 : C30H40O4
纯度 : 99%
分子量 : 464.636
MDL号 : MFCD01711331
存储条件：

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(38.74 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

DMF: 25 mg/mL(53.81 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Pristimerin is a natural product isolated and purified from the herb of Tripterygium wilfordii Hook.f. with anticancer activity. Treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell characteristics and EMT in cancer cells. Pristimerin down-regulates the expression of pro-inflammatory mediators through blocking of NF-κB activation by inhibiting interconnected ROS/IKK/NF-κB signaling pathways, can effectively inhibit both arthritic inflammation and cartilage and bone damage in the joints.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.15mL

0.43mL

0.22mL

10.76mL

2.15mL

1.08mL

21.52mL

4.30mL

2.15mL
参考文献

[1]Liu Y, Gao X, et al. Anticancer agent pristimerin inhibits IL-2 induced activation of T lymphocytes. J Exp Ther Oncol. 2016 Jul;11(3):181-188.