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1-Octanol

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Chemical Structure| 111-87-5 同义名 : 辛醇 ;Octanol
CAS号 : 111-87-5
货号 : A757153
分子式 : C8H18O
纯度 : 98%
分子量 : 130.228
MDL号 : MFCD00002988
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(806.28 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor. 1-octanol inhibited native T-currents at subanesthetic concentrations with an IC(50) of approximately 4 muM. n contrast, 1-octanol was up to 30-fold less potent in inhibiting recombinant Ca(V)3.3 T-channels heterologously expressed in human embryonic kidney cells[3]. Its inhibitory effect was confirmed in vitro and 3 mM 1-octanol totally inhibited spore germination while 100 μM only transiently inhibited spore germination[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

7.68mL

1.54mL

0.77mL

38.39mL

7.68mL

3.84mL

76.79mL

15.36mL

7.68mL
参考文献

[1]Joksovic PM, et al. Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway. Mol Pharmacol. 2010 Jan;77(1):87-94.

[2]Akhtar MK, et al. Microbial production of 1-octanol: A naturally excreted biofuel with diesel-like properties. Metab Eng Commun. 2014 Nov 13;2:1-5.

[3]Joksovic PM, Choe WJ, Nelson MT, Orestes P, Brimelow BC, Todorovic SM. Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway. Mol Pharmacol. 2010 Jan;77(1):87-94

[4]Gillot G, Decourcelle N, Dauer G, Barbier G, Coton E, Delmail D, Mounier J. 1-Octanol, a self-inhibitor of spore germination in Penicillium camemberti. Food Microbiol. 2016 Aug;57:1-7