CCF642

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Chemical Structure| 346640-08-2 同义名 : AC1LYELL
CAS号 : 346640-08-2
货号 : A754516
分子式 : C15H10N2O4S3
纯度 : 99%+
分子量 : 378.446
MDL号 : MFCD01899742
存储条件：

Pure form Keep in dark place,Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(79.27 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CCF642 is a strong inhibitor of protein disulfide isomerases (PDI) with an IC50 of 2.9 μM. It induces acute endoplasmic reticulum (ER) stress in multiple myeloma cells, leading to apoptosis through calcium release. CCF642 is recognized for its extensive anti-multiple myeloma effects. When used at 3 μM for 0.5 to 6 hours, CCF642 enhances PERK dimerization through phosphorylation and IRE1-α oligomerization within 30 minutes in KMS-12-PE cells, indicating the accumulation of misfolded proteins in the ER. As a compound that spares bone marrow, CCF642 shows a submicromolar IC50 across a range of multiple myeloma cell lines (MM1.S, MM1.R, KMS-12-PE, KMS-12-BM, NCI-H929, U266, RPMI 8226, JJN-3, HRMM.09-luc, 5TGM1-luc)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.64mL

0.53mL

0.26mL

13.21mL

2.64mL

1.32mL

26.42mL

5.28mL

2.64mL
参考文献

[1]Vatolin S et al. Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma. Cancer Res. 2016 Jun 1;76(11):3340-50.