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GLX351322

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Chemical Structure| 835598-94-2 同义名 : -
CAS号 : 835598-94-2
货号 : A751215
分子式 : C21H25N3O5S
纯度 : 99%+
分子量 : 431.505
MDL号 : MFCD05123600
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(41.71 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 GLX351322 acts as an inhibitor of NADPH oxidase 4, effectively reducing hydrogen peroxide production in NOX4-overexpressing cells with an IC50 value of 5 μM. It exhibits limited efficacy against NOX2 in hPBMC cells, with an IC50 of 40 μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.32mL

0.46mL

0.23mL

11.59mL

2.32mL

1.16mL

23.17mL

4.63mL

2.32mL
参考文献

[1]Lee HR, Yoo SJ, Kim J, Yoo IS, Park CK, Kang SW. The effect of nicotinamide adenine dinucleotide phosphate oxidase 4 on migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther. 2020 May 15;22(1):116. doi: 10.1186/s13075-020-02204-0. PMID: 32414400; PMCID: PMC7227051.

[2]Anvari E, et al. The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice. Free Radic Res. 2015;49(11):1308-18.