产品说明书

Necrosulfonamide

Print
Chemical Structure| 1360614-48-7 同义名 : -
CAS号 : 1360614-48-7
货号 : A750842
分子式 : C18H15N5O6S2
纯度 : 98+%
分子量 : 461.472
MDL号 : MFCD02370191
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(65.01 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • MLKL
描述 Necrosulfonamide functions as an inhibitor of necroptosis by selectively inhibiting the mixed lineage kinase domain-like protein (MLKL). It obstructs the interaction between the MLKL-RIP1-RIP3 necrosome complex and its subsequent effectors. During necrosis initiation, MLKL is an essential target of RIP3. Necrosulfonamide acts downstream of RIP3 activation to specifically impede necrosis. It hinders necrosis driven by MLKL by inhibiting the functionality of its N-terminal CC domain[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.83mL

2.17mL

1.08mL

21.67mL

4.33mL

2.17mL
参考文献

[1]Sun L, et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 2012;148(1-2):213-227.

[2] Wang H, et al. Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Mol Cell. 2014 Apr 10;54(1):133-146.