产品说明书
BETd-246
 |
同义名 : | - |
| CAS号 : | 2140289-17-2 | |
| 货号 : | A749396 | |
| 分子式 : | C48H55N11O10 | |
| 纯度 : | 98% | |
| 分子量 : | 946.018 | |
| MDL号 : | N/A | |
| 存储条件： |
粉末 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 190 mg/mL(200.84 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | A potent, second-generation BET protein degrader that exhibits superior selectivity, potency and antitumor activity; completely and selectively depletes BRD2, BRD3 and BRD4 in representative TNBC cell lines with 30-100 nM for 1 h or with 10-30 nM for 3 h incubation; displays strong growth inhibition and apoptosis induction activity in TNBC cell lines with IC50 <1 uM, induces a rapid and time-dependent downregulation of MCL1 protein; decreases BET proteins in xenograft breast tumors and suppress tumor growth in vivo without causing weight loss. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.06mL 0.21mL 0.11mL |
5.29mL 1.06mL 0.53mL |
10.57mL 2.11mL 1.06mL |
