产品说明书

BAY 41-2272

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Chemical Structure| 256376-24-6 同义名 : -
CAS号 : 256376-24-6
货号 : A749144
分子式 : C20H17FN6
纯度 : 98%
分子量 : 360.388
MDL号 : MFCD06411391
存储条件:

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 16 mg/mL(44.4 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 BAY 41-2272, an oral and soluble activator of guanylate cyclases (sGC), enhances sGC activity 400-fold in combination with NO. It effectively reduces cardiac workload and boosts cardiac output, making it suitable for cardiovascular disease research[1][2].
作用机制 BAY 41-2272 binds to α1-subunit of sGC through Cys 238 and Cys 243.[1]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.77mL

0.55mL

0.28mL

13.87mL

2.77mL

1.39mL

27.75mL

5.55mL

2.77mL

参考文献

[1]Makrynitsa GI, et al. Mapping of the sGC Stimulator BAY 41-2272 Binding Site on H-NOX Domain and Its Regulation by the Redox State of the Heme. Front Cell Dev Biol. 2022 Jun 17;10:925457.

[2]Vogel J, et al. sGC stimulation lowers elevated blood pressure in a new canine model of resistant hypertension. Hypertens Res. 2021 Dec;44(12):1568-1577.