产品说明书

DPH

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Chemical Structure| 484049-04-9 同义名 : -
CAS号 : 484049-04-9
货号 : A749014
分子式 : C18H13FN4O2
纯度 : 98%
分子量 : 336.32
MDL号 : MFCD03268950
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(148.67 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 DPH is a potent cell permeable c-Abl activator, which displays potent enzymatic and cellular activity in stimulating c-Abl activation.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.97mL

0.59mL

0.30mL

14.87mL

2.97mL

1.49mL

29.73mL

5.95mL

2.97mL
参考文献

[1]Eckes L, Tsokos M, et al. Toxicological identification of diphenhydramine (DPH) in suicide. Forensic Sci Med Pathol. 2013 Jun;9(2):145-53.

[2]Yang J, Campobasso N, et al. Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site. Chem Biol. 2011 Feb 25;18(2):177-86.