产品说明书

Alectinib Hydrochloride

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Chemical Structure| 1256589-74-8 同义名 : CH5424802 Hydrochloride;RO5424802 Hydrochloride;RG-7853;RO5424802;AF802;AF-802 Hydrochloride
CAS号 : 1256589-74-8
货号 : A748062
分子式 : C30H35ClN4O2
纯度 : 98%
分子量 : 519.077
MDL号 : MFCD27987893
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 2 mg/mL(3.85 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor, exhibiting an IC50 of 1.9 nM and a KD value of 2.4 nM (in an ATP-competitive manner). Additionally, it inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib exhibits efficient penetration into the central nervous system (CNS)[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.93mL

0.39mL

0.19mL

9.63mL

1.93mL

0.96mL

19.26mL

3.85mL

1.93mL
参考文献

[1]Sakamoto H, et al. CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell. 2011, 19(5), 679-690.

[2]Gadgeel S, et al. Alectinib versus crizotinib in treatment-naive anaplastic lymphoma kinase-positive (ALK+) non-small-cell lung cancer: CNS efficacy results from the ALEX study. Ann Oncol. 2018 Nov 1;29(11):2214-2222.