H-1152 2HCl

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Chemical Structure| 871543-07-6 同义名 : H-1152 dihydrochloride
CAS号 : 871543-07-6
货号 : A747327
分子式 : C16H23Cl2N3O2S
纯度 : 99%
分子量 : 392.344
MDL号 : MFCD06411451
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 9 mg/mL(22.94 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 35 mg/mL(89.21 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • ROCK2

    ROCK2, IC50:0.0120 μM
描述 H-1152 dihydrochloride, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.55mL

0.51mL

0.25mL

12.74mL

2.55mL

1.27mL

25.49mL

5.10mL

2.55mL
参考文献

[1]Kroll J, Epting D, et al. Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis. Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H893-9.

[2]Ikenoya M, Hidaka H, et al. Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. J Neurochem. 2002 Apr;81(1):9-16.