产品说明书

Cucurbitacin IIb

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Chemical Structure| 50298-90-3 同义名 : 雪胆乙素 ;CuIIb;Dihydrocucurbitacin F;25-deacetyl hemslecin A
CAS号 : 50298-90-3
货号 : A742850
分子式 : C30H48O7
纯度 : 98+%
分子量 : 520.698
MDL号 : MFCD02752610
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(201.65 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • JNK
描述 Cucurbitacin IIb is a natural product isolated and purified from the rhizomes of Hemsleya amabilis Diels.. Cucurbitacin IIb is one of the major active compounds in Hemsleyadine tablets which have been used for clinical treatment of bacillary dysentery, enteritis and acute tonsilitis. Cucurbitacin IIb exhibits its anti-inflammatory activity through modulating multiple cellular behaviors and signaling pathways, leading to the suppression of the adaptive immune response.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.92mL

0.38mL

0.19mL

9.60mL

1.92mL

0.96mL

19.20mL

3.84mL

1.92mL
参考文献

[1]Wang S, Guan X, et al. Simultaneous determination of cucurbitacin IIa and cucurbitacin IIb of Hemsleya amabilis by HPLC-MS/MS and their pharmacokinetic study in normal and indomethacin-induced rats. Biomed Chromatogr. 2016 Oct;30(10):1632-40.

[2]Wang Y, Zhao GX, et al. Cucurbitacin IIb exhibits anti-inflammatory activity through modulating multiple cellular behaviors of mouse lymphocytes. PLoS One. 2014 Feb 25;9(2):e89751.