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Defactinib HCl

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Chemical Structure| 1073160-26-5 同义名 : PF 04554878 hydrochloride;VS-6063 hydrochloride;Defactinib hydrochloride
CAS号 : 1073160-26-5
货号 : A740806
分子式 : C20H22ClF3N8O3S
纯度 : 99%+
分子量 : 546.954
MDL号 : MFCD28144730
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 5 mg/mL(9.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Defactinib (VS-6063) suppresses FAK phosphorylation at the Tyr397 site in both time- and dose-responsive ways. RPPA analysis reveals that Defactinib decreases AKT and YB-1 levels in taxane-resistant cell lines. Defactinib's inhibition of pFAK (Tyr397) expression across all cell lines is statistically significant and dose-dependent. Within 3 hours, Defactinib reduces pFAK (Tyr397) expression, which starts to reappear by 48 hours[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.83mL

0.37mL

0.18mL

9.14mL

1.83mL

0.91mL

18.28mL

3.66mL

1.83mL
参考文献

[1]Kang Y, et al. Role of focal adhesion kinase in regulating YB-1-mediated resistance in ovarian cancer. J Natl Cancer Inst. 2013 Oct 2;105(19):1485-95.