产品说明书

RX-3117

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Chemical Structure| 865838-26-2 同义名 : TV-1360;Fluorocyclopentenylcytosine
CAS号 : 865838-26-2
货号 : A739987
分子式 : C10H12FN3O4
纯度 : 98+%
分子量 : 257.218
MDL号 : MFCD28502078
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(194.39 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 RX-3117 is a cytidine analog showing anticancer activity in several cancer cell lines, including gemcitabine-resistant variants.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.89mL

0.78mL

0.39mL

19.44mL

3.89mL

1.94mL

38.88mL

7.78mL

3.89mL
参考文献

[1]Yang MY, Lee YB, et al. A novel cytidine analog, RX-3117, shows potent efficacy in xenograft models, even in tumors that are resistant to gemcitabine. Anticancer Res. 2014 Dec;34(12):6951-9.

[2]Peters GJ, Smid K, et al. Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine(RX-3117; TV-1360). Invest New Drugs. 2013 Dec;31(6):1444-57.