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Hispidulin

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Chemical Structure| 1447-88-7 同义名 : Dinatin;6-Methoxyapigenin;NSC 122415
CAS号 : 1447-88-7
货号 : A737829
分子式 : C16H12O6
纯度 : 99%+
分子量 : 300.263
MDL号 : MFCD00143504
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(199.82 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Hispidulin, a natural product isolated and purified from the herbs of Ambrosia artemisiifolia Linn., is a Pim-1 inhibitor with an IC50 of 2.71 μM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.33mL

0.67mL

0.33mL

16.65mL

3.33mL

1.67mL

33.30mL

6.66mL

3.33mL
参考文献

[1]Chao SW, Su MY, et al. Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1. J Nat Prod. 2015 Aug 28;78(8):1969-76.

[2]Gao H, Wang H, Peng J. Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k/Akt signalling pathway in HepG2 cancer cells. Cell Biochem Biophys. 2014 May;69(1):27-34.