产品说明书

Mitiglinide calcium hydrate

Print
Chemical Structure| 207844-01-7 同义名 : KAD-1229;S-21403
CAS号 : 207844-01-7
货号 : A737448
分子式 : C38H52CaN2O8
纯度 : 98%
分子量 : 704.906
MDL号 : MFCD08460119
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(35.47 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Mitiglinide calcium hydrate (KAD-1229) is an insulinotropic agent that functions as an antagonist to ATP-sensitive K+ (K_ATP) channels, showing high specificity for the Kir6.2/SUR1 complex, which is the pancreatic beta-cell K_ATP channel. This specificity makes it particularly useful in research related to type 2 diabetes[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.42mL

0.28mL

0.14mL

7.09mL

1.42mL

0.71mL

14.19mL

2.84mL

1.42mL
参考文献

[1]Y Sunaga, et al. The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide. Eur J Pharmacol. 2001 Nov 9;431(1):119-25.

[2]Kiyoshi Ichikawa, et al. Effect of KAD-1229, a novel hypoglycaemic agent, on plasma glucose levels after meal load in type 2 diabetic rats. Clin Exp Pharmacol Physiol. May-Jun 2002;29(5-6):423-7.