产品说明书

ML-098

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Chemical Structure| 878978-76-8 同义名 : CID-7345532
CAS号 : 878978-76-8
货号 : A736431
分子式 : C19H19NO3
纯度 : 99%
分子量 : 309.359
MDL号 : MFCD08672264
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(96.97 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ML-098 (CID-7345532) operates by enhancing the affinity of the GTPases for guanine nucleotides, suggesting that these activators interact with allosteric binding sites situated between switch regions I and II. ML-098 serves as an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM, displaying selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (with EC50s of 588.8, 346.7, 158.5, and 794.3 nM, respectively) [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.23mL

0.65mL

0.32mL

16.16mL

3.23mL

1.62mL

32.32mL

6.46mL

3.23mL
参考文献

[1]Zurab Surviladze, et al. Three small molecule pan activator families of Ras-related GTPases. National Center for Biotechnology Information (US); 2010–.2009 May 18.