产品说明书

ETP-46464

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Chemical Structure| 1345675-02-6 同义名 : ATM Inhibitor III;ATR Inhibitor III
CAS号 : 1345675-02-6
货号 : A734915
分子式 : C30H22N4O2
纯度 : 98%
分子量 : 470.521
MDL号 : MFCD23160051
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(8.5 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • mTOR

    mTOR, IC50:0.6 nM

  • ATM

    ATM, IC50:545 nM

  • ATR

    ATR, IC50:14 nM
描述 ETP-46464 is a cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα, and ATM (IC50= 0.6, 14, 36, 170, and 545 nM, respectively).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.13mL

0.43mL

0.21mL

10.63mL

2.13mL

1.06mL

21.25mL

4.25mL

2.13mL
参考文献

[1]Toledo LI, Murga M, et al. A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nat Struct Mol Biol. 2011 Jun;18(6):721-7.