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Eudesmin

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Chemical Structure| 526-06-7 同义名 : (-)-Eudesmin;(-)-Eudesmine;Eudesmine
CAS号 : 526-06-7
货号 : A730957
分子式 : C22H26O6
纯度 : 98+%
分子量 : 386.438
MDL号 : MFCD00274496
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(271.71 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Eudesmin, a natural product isolated and purified from the dry leaves of Haplophyllum perforatum Kar.et Kir. with antiinflammatory effects, can significantly inhibit TNF-alpha production by lipopolysaccharide (LPS)-stimulated murine macrophage RAW264.7 without displaying cytotoxicity, and can significantly attenuate T cell proliferation stimulated by concanavalin A (Con A) in a dose-dependent manner. Eudesmin can induce vascular relaxation in rat aorta, which is mediated by release of nitric oxide and prostanoid through the involvement of histamine receptor present in the endothelial cells, and can induce neurite outgrowth and enhance nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways at a concentration of 50 mM, showing neuritogenic activity. Eudesmin also has significant anticonvulsant and sedative effects, and the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.59mL

0.52mL

0.26mL

12.94mL

2.59mL

1.29mL

25.88mL

5.18mL

2.59mL
参考文献

[1]Cho JY, Yoo ES, et al. Eudesmin inhibits tumor necrosis factor-alpha production and T cell proliferation. Arch Pharm Res. 1999 Aug;22(4):348-53.

[2]Raimundo JM, Trindade AP, et al. The lignan eudesmin extracted from Piper truncatum induced vascular relaxation via activation of endothelial histamine H1 receptors. Eur J Pharmacol. 2009 Mar 15;606(1-3):150-4.