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MG 149

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Chemical Structure| 1243583-85-8 同义名 : Tip60 HAT inhibitor
CAS号 : 1243583-85-8
货号 : A728121
分子式 : C22H28O3
纯度 : 99%+
分子量 : 340.456
MDL号 : MFCD22123243
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(308.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 MG149 is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.94mL

0.59mL

0.29mL

14.69mL

2.94mL

1.47mL

29.37mL

5.87mL

2.94mL
参考文献

[1]Legartova S, Stixova L, et al. Basic nuclear processes affected by histone acetyltransferases and histone deacetylase inhibitors. Epigenomics. 2013 Aug;5(4):379-96.

[2]Ghizzoni M, Wu J, et al. 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur J Med Chem. 2012 Jan;47(1):337-44.