产品说明书
Triprolidine HCl monohydrate
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同义名 : | 盐酸曲普利啶 ;Triprolidine Hydrochloride;Triprolidine hydrochloride monohydrate |
| CAS号 : | 6138-79-0 | |
| 货号 : | A728042 | |
| 分子式 : | C19H25ClN2O | |
| 纯度 : | 99% | |
| 分子量 : | 332.868 | |
| MDL号 : | MFCD00150574 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(315.44 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(300.42 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Triprolidine HCl is a hydrochloride resulting from the formal reaction of equimolar amounts of triprolidine and hydrogen chloride. Its monohydrate is used for the symptomatic relief of uticaria, rhinitis, and various pruritic skin disorders. It has a role as a H1-receptor antagonist. It contains a triprolidine(1+). The absolute oral bioavailability of triprolidine (1-mg/kg dose) in the dog was low (4%). A comparison of triprolidine pharmacokinetic parameters in dogs, rabbits, rats, and humans revealed considerable similarity in elimination characteristics in these species[1]. of 0, 250, 1000, or 2000 ppm (as the free base) to groups of 60 Fischer 344 (F344) rats of each sex for up to 2 years to evaluate its potential carcinogenicity. Survival was significantly extended in triprolidine-treated males and females, particularly at the high dose. At the close of the study high-dose males and females had gained significantly less body weight than controls. Triprolidine was not carcinogenic in F344 rats[2]. The permeation rate of triprolidine in the stripped skin was greatly larger than that in the whole skin. The permeability of triprolidine was markedly increased with stripping of the mouse skin to remove the stratum corneum that acts as a barrier of skin permeation[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.00mL 0.60mL 0.30mL |
15.02mL 3.00mL 1.50mL |
30.04mL 6.01mL 3.00mL |
| 参考文献 |
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