产品说明书

ITI-214

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Chemical Structure| 1642303-38-5 同义名 : -
CAS号 : 1642303-38-5
货号 : A726292
分子式 : C29H29FN7O5P
纯度 : 99%+
分子量 : 605.557
MDL号 : MFCD28385868
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(49.54 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ITI-214 is a powerful, CNS-penetrant, orally bioavailable inhibitor of PDE1 (with a Ki of 58 pM), boasting remarkable selectivity over other PDE family enzymes as well as a broad spectrum of enzymes, receptors, transporters, and ion channels. It inhibits recombinant full-length human PDE1A, PDE1B, and PDE1C with Ki values of 33 pM, 380 pM, and 35 pM, respectively. ITI-214 has demonstrated effectiveness in various animal models addressing motor and cognitive functions[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.65mL

0.33mL

0.17mL

8.26mL

1.65mL

0.83mL

16.51mL

3.30mL

1.65mL
参考文献

[1]Li P, et al. Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases. J Med Chem. 2016;59(3):1149-1164.

[2]Snyder GL, et al. Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats. Psychopharmacology (Berl). 2016;233(17):3113-3124.