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Cloperastine fendizoate

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Chemical Structure| 85187-37-7 同义名 : -
CAS号 : 85187-37-7
货号 : A725210
分子式 : C40H38ClNO5
纯度 : 98%
分子量 : 648.186
MDL号 : MFCD01661515
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 9 mg/mL(13.88 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Cloperastine disrupts hERG K+ currents in a concentration-dependent manner, displaying an IC50 value of 27±3 nM[1]. As an antitussive agent, cloperastine exhibits both antitussive and antiedemic activities and has the ability to relax bronchial musculature. It operates primarily through a central antitussive mechanism and has antihistaminic and papaverine-like activities, comparable to those of codeine but without the associated narcotic effects[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.54mL

0.31mL

0.15mL

7.71mL

1.54mL

0.77mL

15.43mL

3.09mL

1.54mL
参考文献

[1]Takahara A, et al. Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs. J Pharmacol Sci. 2012;120(3):165-75.

[2]Catania MA, et al. Pharmacological and clinical overview of cloperastine in treatment of cough. Ther Clin Risk Manag. 2011;7:83-92.