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Diquafosol tetrasodium

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Chemical Structure| 211427-08-6 同义名 : INS365;Diquafosol (sodium salt);KPY 998
CAS号 : 211427-08-6
货号 : A725206
分子式 : C18H22N4Na4O23P4
纯度 : 99%+
分子量 : 878.234
MDL号 : MFCD18071356
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 1 mg/mL(1.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(113.86 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 In another context, cell viability significantly diminishes following a 1-hour exposure to 30% diluted diquafosol, and continues to decrease 6 hours after treatment with 10% and 20% diluted diquafosol. Additionally, 24 hours after wounding monolayers, treatments with 3% diquafosol and 0.3% HCECs demonstrate significantly enhanced wound healing compared to the control[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.14mL

0.23mL

0.11mL

5.69mL

1.14mL

0.57mL

11.39mL

2.28mL

1.14mL
参考文献

[1]Lee JH, et al. Comparison of cytotoxicities and wound healing effects of diquafosol tetrasodium and hyaluronic acid on human corneal epithelial cells. Korean J Physiol Pharmacol. 2017 Mar;21(2):189-195.

[2]Fujihara T, et al. Improvement of corneal barrier function by the P2Y(2) agonist INS365 in a rat dry eye model. Invest Ophthalmol Vis Sci. 2001 Jan;42(1):96-100.

[3]Fujihara T, et al. INS365 suppresses loss of corneal epithelial integrity by secretion of mucin-like glycoprotein in a rabbit short-term dry eye model. J Ocul Pharmacol Ther. 2002 Aug;18(4):363-70.