产品说明书

(+)-SJ733

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Chemical Structure| 1424799-20-1 同义名 : SJ000557733
CAS号 : 1424799-20-1
货号 : A725081
分子式 : C24H16F4N4O2
纯度 : 99%+
分子量 : 468.403
MDL号 : MFCD30532619
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(106.75 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 (+)-SJ733 is an anti-malaria agent which can also inhibit Na+-ATPase PfATP4[1]. Acting as an anti-malarial compound, (+)-SJ733 also serves to impede the Na+-ATPase PfATP4 enzyme[1]. The agent attaches itself to a unique receptor on P. falciparum-infected red blood cells, demonstrating a binding affinity equal to its inhibitory effect on growth (kd=50 nM). In comprehensive in vitro analyses and various in vivo dose-regimen studies, (+)-SJ733 revealed no significant safety or tolerability issues across any tested dosages in preclinical models, showcasing a no observed adverse effect level and a maximum tolerated dose exceeding 240 mg/kg from a study over seven days of repeated dosing in rats. Consequently, (+)-SJ733 is projected to possess a safety buffer of at least 43 times[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.13mL

0.43mL

0.21mL

10.67mL

2.13mL

1.07mL

21.35mL

4.27mL

2.13mL
参考文献

[1]Jimenez-Diaz MB, et al. (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5455-62.