生物活性 | |||
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描述 | LP-533401 is a Tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut. LP-533401 completely inhibits serotonin production in Tph1–expressing cells (RBL2H3 cells) at a dose of 1 μM[1]. | ||
作用机制 | LP-533401 interacts with two amino acids, Tyr235 and Phe241, near Tph1 catalytic site. [2] |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.90mL 0.38mL 0.19mL |
9.50mL 1.90mL 0.95mL |
18.99mL 3.80mL 1.90mL |
参考文献 |
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