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Pitofenone HCl

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Chemical Structure| 1248-42-6 同义名 : Pitofenone (hydrochloride);Pitofenone hydrochloride
CAS号 : 1248-42-6
货号 : A724539
分子式 : C22H26ClNO4
纯度 : 98%
分子量 : 403.899
MDL号 : MFCD01661944
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(210.45 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(247.59 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Pitofenone HCl, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36 and 45 μM, respectively[1]. Pitofenone (10-3 mol/l) antagonized completely spontaneous phasic-rhythmic as well as norepinephrine- or acetylcholine-induced phasic activity. Pitofenone (10-6 to 10-3 mol/l) antagonized the high potassium-induced activation in a concentration-dependent way. The EC50 of pitofenone amounted to 2 X 10-4 mol/l. Pitofenone has a direct relaxant effect on smooth muscle of the upper urinary tract, whereas fenpiverinium has exclusively anticholinergic properties[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.48mL

0.50mL

0.25mL

12.38mL

2.48mL

1.24mL

24.76mL

4.95mL

2.48mL
参考文献

[1]Punekar NS, Kulkarni AV. Acetylcholinesterase inhibition by pitofenone: a spasmolytic compound. Biotechnol Appl Biochem. 1991 Dec;14(3):378-82

[2]Hertle L, Nawrath H. Zur Wirkung von Baralgin auf isolierte Präparate des menschlichen oberen Harntraktes [Effect of Baralgin on isolated preparations of the upper urinary tract in man]. Urol Int. 1984;39(2):84-90. German