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PF-06726304

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Chemical Structure| 1616287-82-1 同义名 : PF-6726304
CAS号 : 1616287-82-1
货号 : A724309
分子式 : C22H21Cl2N3O3
纯度 : 99%+
分子量 : 446.326
MDL号 : MFCD31563584
存储条件：

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 14 mg/mL(31.37 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 PF-06726304 is a potent and selective EZH2 inhibitor. PF-06726304 inhibited EZH2-WT and EZH2-Y641N mutant with Ki values of 0.7 and 3.0 nM, respectively. PF-06726304 inhibited H3K27me3 in Karpas-422 with an IC50 value of 15 nM. PF-06726304 has strong anti-tumour growth activity[1]. PF-06726304 inhibited the proliferation of Karpas-422 cells carrying wild-type EZH2 with an IC50 of 25 nM[1] .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.24mL

0.45mL

0.22mL

11.20mL

2.24mL

1.12mL

22.41mL

4.48mL

2.24mL
参考文献

[1]Kung PP, et al. Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors. J Med Chem. 2016 Sep 22;59(18):8306-25.