产品说明书
MHP
 |
同义名 : | Defensamide;Methyl caprooyl tyrosinate |
| CAS号 : | 1104874-94-3 | |
| 货号 : | A723946 | |
| 分子式 : | C16H23NO4 | |
| 纯度 : | 99%+ | |
| 分子量 : | 293.358 | |
| MDL号 : | MFCD31382170 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(357.92 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Defensamide is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production. Sphingosine kinase (SPHK) is a conserved lipid kinase that is essential in the production of sphingosine-1-phosphate (S1P) from the precursor sphingolipid sphingosine. Defensamide plays a potential role of in modulating innate epidermal antimicrobial defense by upregulating CAMP production[1]. Defensamide directly activated SPHK1 and increased cellular S1P content in normal cultured human keratinocytes. Treatment with defensamide (50 – 250 μM) shows a significant dose-dependent increase in CAMP mRNA expression in human keratinocytes through qRT-PCR analyses. Also, defensamide treatment significantly increased cellular S1P levels by activation of SPHK1, but not S1P lyase activity[1]. Defensamide activation of SPHK1 can stimulate innate immunity, and defensamide significantly suppressed invasion of the virulent Staphylococcus aureus into murine skin explants[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.41mL 0.68mL 0.34mL |
17.04mL 3.41mL 1.70mL |
34.09mL 6.82mL 3.41mL |
| 参考文献 |
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