产品说明书

CA-170

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Chemical Structure| 1673534-76-3 同义名 : Pd-1-in-1;AUPM-170;Aurigene 1;PD1-IN-1. PD-L1/PD-L2/VISTA antagonist;PD-1-IN17;PD-1-IN-1 free base
CAS号 : 1673534-76-3
货号 : A723757
分子式 : C12H20N6O7
纯度 : 97% (contains 2.7% ethanol)
分子量 : 360.323
MDL号 : MFCD30738000
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(69.38 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • PD-L1
描述 CA-170 is an oral inhibitor targeting both VISTA and PD-L1. It effectively restores the proliferative and effector capabilities of T cells that are suppressed by PD-L1/L2 and VISTA. CA-170 is selective, favoring these immune checkpoints over a wide array of other immune proteins, receptors, and enzymes[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.78mL

0.56mL

0.28mL

13.88mL

2.78mL

1.39mL

27.75mL

5.55mL

2.78mL
参考文献

[1]Pottayil Govindan Nair Sasikumar, et al. 1,2,4-oxadiazole derivatives as immunomodulators. WO2015033299A1.