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Chebulinic acid

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Chemical Structure| 18942-26-2 同义名 : Eutannin;NSC 69862
CAS号 : 18942-26-2
货号 : A723745
分子式 : C41H32O27
纯度 : 98%
分子量 : 956.677
MDL号 : MFCD06656295
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(109.75 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.05mL

0.21mL

0.10mL

5.23mL

1.05mL

0.52mL

10.45mL

2.09mL

1.05mL
参考文献

[1]Patel K, Tyagi C, et al. Identification of chebulinic acid as potent natural inhibitor of M. tuberculosis DNA gyrase and molecular insights into its binding mode of action. Comput Biol Chem. 2015 Dec;59 Pt A:37-47.

[2]Sivasankar S, Lavanya R, et al. Aqueous and alcoholic extracts of Triphala and their active compounds chebulagic acid and chebulinic acid prevented epithelial to mesenchymal transition in retinal pigment epithelial cells, by inhibiting SMAD-3 phosphorylation. PLoS One. 2015 Mar 20;10(3):e0120512.