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ER-000444793

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Chemical Structure| 792957-74-5 同义名 : -
CAS号 : 792957-74-5
货号 : A723727
分子式 : C23H18N2O2
纯度 : 98%+
分子量 : 354.401
MDL号 : MFCD31544321
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(141.08 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ER-000444793, a non-toxic inhibitor of the mPTP, operates through a mechanism distinct from CypD inhibition. It effectively and in a dose-responsive manner curtails Ca2+-induced mitochondrial permeability transition (mPT). While ER-000444793 does bind to CypD, it does not displace labelled-CsA from rhCypD protein up to 50 μM, as evidenced by a CsA/CypD HTRF assay. This is in contrast to CsA and SfA, which both reduce the HTRF signal in a dose-dependent manner, indicating their displacement of labelled CsA (with IC50 values of 23 nM and 5 nM, respectively). These findings indicate that ER-000444793's ability to delay mPT is not reliant on inhibiting CypD function[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.82mL

0.56mL

0.28mL

14.11mL

2.82mL

1.41mL

28.22mL

5.64mL

2.82mL
参考文献

[1]Briston T, et al. Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria. Sci Rep. 2016 Nov 25;6:37798.