产品说明书

RA190

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Chemical Structure| 1617495-03-0 同义名 : -
CAS号 : 1617495-03-0
货号 : A723706
分子式 : C28H23Cl5N2O2
纯度 : 98%
分子量 : 596.759
MDL号 : MFCD30738021
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(175.95 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 RA190 forms a covalent bond with cysteine 88 on the RPN13 ubiquitin receptor within the 19S regulatory particle, leading to proteasome inhibition and a swift build-up of polyubiquitinated proteins. It is effective against multiple myeloma (MM) cell lines, including those that are bortezomib-resistant, by inducing apoptosis through endoplasmic reticulum stress. Additionally, RA190 impedes the degradation of human papillomavirus (HPV) E6 oncoprotein targets, resulting in the selective elimination of HPV-transformed cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.68mL

0.34mL

0.17mL

8.38mL

1.68mL

0.84mL

16.76mL

3.35mL

1.68mL
参考文献

[1]Anchoori RK, et al. A bis-benzylidine piperidone targeting proteasome ubiquitin receptor RPN13/ADRM1 as a therapy for cancer. Cancer Cell. 2013 Dec 9;24(6):791-805.