ML349

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Chemical Structure| 890819-86-0 同义名 : -
CAS号 : 890819-86-0
货号 : A723701
分子式 : C23H22N2O4S2
纯度 : 98%
分子量 : 454.562
MDL号 : MFCD14808090
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(39.6 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ML349, identified as a strong and selective inhibitor for APT2 and LYPLA2, has a Ki of 120 nM and an IC50 of 144 nM. It exhibits high selectivity for LYPLA2 over LYPLA1, with Ki values for APT-1 and APT-2 being >10000 nM and 120±20 nM, respectively. Furthermore, ML349 inhibits both LYPLA1 and LYPLA2 with IC50s of >3000 nM and 144 nM, respectively[1][2]. ML348 and ML349 are not associated with a reduction in cell viability; however, they induce a minor activation of the AKT pathway in cells with NRAS mutations[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.20mL

0.44mL

0.22mL

11.00mL

2.20mL

1.10mL

22.00mL

4.40mL

2.20mL
参考文献

[1]Won SJ, et al. Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). ACS Chem Biol. 2016 Dec 16;11(12):3374-3382.

[2]Adibekian A, et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2).

[3]Vujic I, et al. Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget. 2016 Feb 9;7(6):7297-306.