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Pimpinellin

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Chemical Structure| 131-12-4 同义名 : -
CAS号 : 131-12-4
货号 : A723402
分子式 : C13H10O5
纯度 : 99%+
分子量 : 246.215
MDL号 : MFCD00597237
存储条件:

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(426.46 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Pimpinellin, a natural product isolated and purified from the fruits of Psoralea corylifolia L. with phototoxic activity and inhibitory effects LPS-induced inflammatory response in RAW264.7 macrophages and Mycobacterium tuberculosis strain H37Ra , with MICs of 812 uM and IC50s of 389 uM. Pimpinellin also has potent cytotoxic activities against the three cell lines(MGC-803, PC3, and A375), with the IC50 values of 14.4±0.3uM, 20.4±0.5uM, and 29.2±0.6uM, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.06mL

0.81mL

0.41mL

20.31mL

4.06mL

2.03mL

40.61mL

8.12mL

4.06mL

参考文献

[1]Cervi A, Aillard P, et al. Total syntheses of the coumarin-containing natural products pimpinellin and fraxetin using Au(I)-catalyzed intramolecular hydroarylation (IMHA) chemistry. J Org Chem. 2013 Oct 4;78(19):9876-82.

[2]Liu Z, Jiang M, et al. Simultaneous determination of pimpinellin, isopimpinellin and phellopterin in rat plasma by a validated UPLC-MS/MS and its application to a pharmacokinetic study after administration of Toddalia asiatica extract. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Apr 1;891-892:102-8.