产品说明书
Loganic acid
 |
同义名 : | Loganate;Loganin Acid;Loganin Acid, Loganate |
| CAS号 : | 22255-40-9 | |
| 货号 : | A722969 | |
| 分子式 : | C16H24O10 | |
| 纯度 : | 99%+ | |
| 分子量 : | 376.356 | |
| MDL号 : | MFCD00017417 | |
| 存储条件： |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 50 mg/mL(132.85 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Loganic acid is an iridoid isolated from cornelian cherry fruits. Loganic acid (an iridoid) diminished the formation of atherosclerotic plaques in the aorta. It also diminished lipid peroxidation, measured as a decrease of MDA, and attenuated oxidative stress, measured as an increase of GSH in the livers depleted by cholesterol feeding[3]. Loganic acid has strong free radical scavenging activity and remarkable cyto-protective effect against heavy metal mediated toxicity[4]. Treatment with loganic acid significantly increased osteoblastic differentiation in preosteoblast MC3T3-E1 cells by promoting alkaline phosphatase activity and increasing mRNA expression levels of bone metabolic markers such as Alpl, Bglap, and Sp7. However, loganic acid inhibited osteoclast differentiation of primary-cultured monocytes derived from mouse bone marrow. Loganic acid prevented OVX-induced bone mineral density loss and improved bone structural properties in osteoporotic model mice[5]. LA (Loganic Acid) showed a restoration of balance between functioning of antioxidant defense system and oxidative stress in leukocytes without notable effects on blood glucose levels when administered orally to rats (20 mg/kg b.w./day) for 14 days. LA ameliorated antioxidant status in leukocytes, as indicated by increasing the content of reduced glutathione and activities of catalase, glutathione peroxidase and glutathione reductase along with decreasing levels of intracellular reactive oxygen species[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.66mL 0.53mL 0.27mL |
13.29mL 2.66mL 1.33mL |
26.57mL 5.31mL 2.66mL |
| 参考文献 |
|---|