产品说明书

Balovaptan

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Chemical Structure| 1228088-30-9 同义名 : RG7314
CAS号 : 1228088-30-9
货号 : A718871
分子式 : C22H24ClN5O
纯度 : 99%+
分子量 : 409.912
MDL号 : MFCD31706224
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(121.98 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Balovaptan , also known as RG7314, is an orally potent, selective, blood-brain barrier-crossing vasopressin 1a (hV1a) receptor antagonist with Ki values of 1 and 39 nM for human and mouse (hV1a, mV1a) receptors, respectively, and can be used in autism research[1].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02901431 Autism Spectrum Disorder Phase 2 Recruiting April 18, 2019 -
NCT03586726 Healthy Volunteers Phase 1 Active, not recruiting November 15, 2018 Netherlands ... 展开 >> Pra International Group B.V Groningen, Netherlands, 9728 NZ 收起 <<
NCT03504917 Autism Spectrum Disorder Phase 3 Recruiting March 31, 2023 -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.44mL

0.49mL

0.24mL

12.20mL

2.44mL

1.22mL

24.40mL

4.88mL

2.44mL
参考文献

[1]Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12;58(5):2275-89.