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D-Tetrahydropalmatine

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Chemical Structure| 3520-14-7 同义名 : (+)-Corydalis B;D-THP;(R)-Tetrahydropalmatine;(+)-Tetrahydropalmatine
CAS号 : 3520-14-7
货号 : A711877
分子式 : C21H25NO4
纯度 : 98+%
分子量 : 355.428
MDL号 : MFCD11046348
存储条件：

粉末 2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(140.68 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 D-Tetrahydropalmatine, a natural product isolated and purified from the barks of Phellodendron chinense Schneid, is an organic cation transporter 1 (OCT1) inhibitor, and obviously inhibits the uptake of MCT in MDCK-hOCT1 cells and isolated rat primary hepatocytes, and attenuates the viability reduction and LDH release of the primary cultured rat hepatocytes caused by MCT.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.81mL

0.56mL

0.28mL

14.07mL

2.81mL

1.41mL

28.14mL

5.63mL

2.81mL
参考文献

[1]Tu M, Sun S, et al. Organic cation transporter 1 mediates the uptake of monocrotaline and plays an important role in its hepatotoxicity. Toxicology. 2013 Sep 15;311(3):225-30.

[2]Xu SX, Yu LP, et al. Effects of tetrahydroprotoberberines on dopamine receptor subtypes in brain. Zhongguo Yao Li Xue Bao. 1989 Mar;10(2):104-10. Chinese.