Y-33075

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Chemical Structure| 199433-58-4 同义名 : Y-39983 free base;RKI-983;Y-39983;SNJ-1656
CAS号 : 199433-58-4
货号 : A709627
分子式 : C16H16N4O
纯度 : 98+%
分子量 : 280.324
MDL号 : MFCD16038858
存储条件：

Pure form

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(178.36 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Y-33075 is potent and selective p160 ROCK inhibitor with an Ki value of 0.14 μM, > 200 fold selectivity for p160ROCK than PKC, cAMP-dependent protein kianse and Mypsin light-chain kinase.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.57mL

0.71mL

0.36mL

17.84mL

3.57mL

1.78mL

35.67mL

7.13mL

3.57mL
参考文献

[1]Gao C, Huang L, et al. Y-39983, a selective Rho-kinase inhibitor, attenuates experimental autoimmune encephalomyelitis via inhibition of demyelination. Neuroimmunomodulation. 2013;20(6):334-40.

[2]Yang Z, Wang J, et la. Y-39983 downregulates RhoA/Rho-associated kinase expression during its promotion of axonal regeneration. Oncol Rep. 2013 Mar;29(3):1140-6.