产品说明书

Rislenemdaz

Print
Chemical Structure| 808732-98-1 同义名 : MK-0657;CERC-301
CAS号 : 808732-98-1
货号 : A709210
分子式 : C19H23FN4O2
纯度 : 98%
分子量 : 358.41
MDL号 : MFCD14635204
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(292.96 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Rislenemdaz, also known as CERC-301, inhibits calcium influx agonist-stimulated NMDA-GluN1a/GluN2B L(tk-) cells with an IC50 of 3.6 nM. Rislenemdaz is at least 1000-fold more selective for the GluN2B receptor compared to all targets tested, including hERG potassium channels. At 10 uM, Rislenemdaz is also minimally active against sigma-type receptors[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.79mL

0.56mL

0.28mL

13.95mL

2.79mL

1.40mL

27.90mL

5.58mL

2.79mL
参考文献

[1]Rachel Garner, et al. Preclinical pharmacology and pharmacokinetics of CERC‐301, a GluN2B‐selective N‐methyl‐D‐aspartate receptor antagonist. Pharmacol Res Perspect. 2015 Dec; 3(6): e00198.