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Mycro 3

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Chemical Structure| 944547-46-0 同义名 : -
CAS号 : 944547-46-0
货号 : A708851
分子式 : C24H17ClF2N6O4
纯度 : 99%+
分子量 : 526.879
MDL号 : MFCD03409284
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(199.29 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 The proto-oncogene c-myc encodes a transcription factor c-Myc, which is of great importance in controlling cell growth and vitality[1]. The heterodimerization of c-Myc with Myc-associated factor X (MAX) plays a critical role in the proliferation, transformation, and apoptosis. Mycro3 is a small-molecule inhibitor of Myc-Max dimerization and also inhibit c-Myc/Max/DNA binding[2]. c-Myc has become an interesting and feasible target for novel therapies of a variety of human malignancies related to c-Myc, Mycro3 may be a novel and effective therapeutic agents to treat cancer. Mechanism: Mycro-3 is shown to bind one of the three discrete binding sites on the c-Myc bHLH-Zip domain[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.90mL

0.38mL

0.19mL

9.49mL

1.90mL

0.95mL

18.98mL

3.80mL

1.90mL
参考文献

[1]Thompson EB. The many roles of c-Myc in apoptosis. Annu Rev Physiol. 1998;60:575-600.

[2]Chen BJ, Wu YL, Tanaka Y, Zhang W. Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics. Int J Biol Sci. 2014;10(10):1084-1096.

[3]Chen BJ, Wu YL, Tanaka Y, Zhang W. Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics. Int J Biol Sci. 2014;10(10):1084-1096.