Trifluridine/tipiracil HCl mixture
产品说明书
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同义名 : | TAS-102;FTD/TPI;TAS102, TAS-102, TAS 102, Trifluridine/tipiracil hydrochloride;Trifluridine-Tipiracil Hydrochloride Mixture;Trifluridine/tipiracil hydrochloride mixture |
| CAS号 : | 733030-01-8 | |
| 货号 : | A705747 | |
| 分子式 : | C19H23Cl2F3N6O7 | |
| 纯度 : | 98% | |
| 分子量 : | 575.323 | |
| MDL号 : | MFCD30481309 | |
| 存储条件： |
Pure form Inert atmosphere,Store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 2 mg/mL(3.48 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(173.82 mM)，配合低频超声助溶 DMF: 20 mg/mL(34.76 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | The Trifluridine/tipiracil hydrochloride mixture (TAS-102) is an effective and orally active nucleoside antitumor agent. Comprised of a 1:0.5 molar ratio of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI), TAS-102 exerts its antitumor effects predominantly through the inhibition of thymidylate synthase (TS) and by being incorporated into DNA[1].[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.74mL 0.35mL 0.17mL |
8.69mL 1.74mL 0.87mL |
17.38mL 3.48mL 1.74mL |
| 参考文献 |
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