Adenosine 5'-monophosphate monohydrate
产品说明书
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同义名 : | 5'-AMP monohydrate;5'-Adenylic acid;5'-AMP |
| CAS号 : | 18422-05-4 | |
| 货号 : | A705530 | |
| 分子式 : | C10H16N5O8P | |
| 纯度 : | 95% | |
| 分子量 : | 365.236 | |
| MDL号 : | MFCD00005750 | |
| 存储条件： |
Pure form Keep in dark place,Inert atmosphere,Store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
H2O: 5 mg/mL(13.69 mM) |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Adenosine 5'-monophosphate monohydrate functions as an agonist for the adenosine A1 receptor[1]. In cell studies using RAW264.7 cells, Adenosine 5'-monophosphate monohydrate demonstrates minimal cytotoxicity at concentrations ranging from 25 to 400 μM. Notably, it significantly reduces mRNA levels of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in a dose-dependent manner, with the most substantial suppression observed at 400 μM. Additionally, it impedes the recruitment of the NF-κB p65 subunit to the promoters of TNF-α, IL-6, and IL-1β genes, thereby inhibiting their expression[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.74mL 0.55mL 0.27mL |
13.69mL 2.74mL 1.37mL |
27.38mL 5.48mL 2.74mL |
| 参考文献 |
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