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Adenosine 5'-monophosphate monohydrate

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Chemical Structure| 18422-05-4 同义名 : 5'-AMP monohydrate;5'-Adenylic acid;5'-AMP
CAS号 : 18422-05-4
货号 : A705530
分子式 : C10H16N5O8P
纯度 : 95%
分子量 : 365.236
MDL号 : MFCD00005750
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 5 mg/mL(13.69 mM)
动物实验配方：
生物活性
描述 Adenosine 5'-monophosphate monohydrate functions as an agonist for the adenosine A1 receptor[1]. In cell studies using RAW264.7 cells, Adenosine 5'-monophosphate monohydrate demonstrates minimal cytotoxicity at concentrations ranging from 25 to 400 μM. Notably, it significantly reduces mRNA levels of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in a dose-dependent manner, with the most substantial suppression observed at 400 μM. Additionally, it impedes the recruitment of the NF-κB p65 subunit to the promoters of TNF-α, IL-6, and IL-1β genes, thereby inhibiting their expression[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.74mL

0.55mL

0.27mL

13.69mL

2.74mL

1.37mL

27.38mL

5.48mL

2.74mL
参考文献

[1]Rittiner JE, et al. AMP is an adenosine A1 receptor agonist. J Biol Chem. 2012 Feb 17;287(8):5301-9.

[2]Zhan Y, et al. Adenosine 5'-monophosphate ameliorates D-galactosamine/lipopolysaccharide-induced liver injury through an adenosine receptor-independent mechanism in mice. Cell Death Dis. 2014 Jan 9;5:e985.