14-Deoxyandrographolide

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Chemical Structure| 4176-97-0 同义名 : 去氧穿心莲内酯 ;14-DAG
CAS号 : 4176-97-0
货号 : A701951
分子式 : C20H30O4
纯度 : 98+%
分子量 : 334.45
MDL号 : MFCD01861504
存储条件:

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(313.95 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 14-Deoxyandrographolide, a natural product isolated and purified from the herbs of Andrographis paniculata (Burm. f.) Nees with hepatoprotective activity, mediates activation of adenylate cyclase-cAMP signaling leading to up-regulation of cNOS, probably providing a promising approach in the prevention of liver diseases during chronic alcoholism, and desensitizes hepatocytes to TNF-alpha-mediated apoptosis through the release of TNFRSF1A.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.99mL

0.60mL

0.30mL

14.95mL

2.99mL

1.49mL

29.90mL

5.98mL

2.99mL

参考文献

[1]Mandal S, Mukhopadhyay S, et al. 14-Deoxyandrographolide alleviates ethanol-induced hepatosteatosis through stimulation of AMP-activated protein kinase activity in rats. Alcohol. 2014 Mar;48(2):123-32.

[2]Mandal S, Nelson VK, et al. 14-Deoxyandrographolide targets adenylate cyclase and prevents ethanol-induced liver injury through constitutive NOS dependent reduced redox signaling in rats. Food Chem Toxicol. 2013 Sep;59:236-48.