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Famotidine

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Chemical Structure| 76824-35-6 同义名 : MK-208;YM-11170;Famotidine, Famotidine Hydrochloride, MK-208, Pepcid, YM-11170, YM11170, YM 11170, MK 208, MK208
CAS号 : 76824-35-6
货号 : A701177
分子式 : C8H15N7O2S3
纯度 : 97%
分子量 : 337.44
MDL号 : MFCD00079297
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(311.17 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • H2 receptor
描述 Famotidine is a histamine-2 receptor antagonists. Steers received IV famotidine (0.4 mg/kg) as a single and 3-dose regimen (every 8 hours) versus saline control. Abomasal outflow fluid pH was higher in steers treated with famotidine for up to 4 hours after a single dose but the effect decreased with subsequent doses. Famotidine may be useful for treatment or prevention of abomasal ulceration in adult cattle, but the duration of effect may decrease with time[2]. Continued administration of famotidine results in a diminished effect on intragastric pH in dogs[3]. A famotidine CRI (continuous rate infusion), but not standard doses of famotidine, achieves the clinical goals established in people to promote healing of gastric tissue injury and offers an alternative to intravenous treatment with proton pump inhibitors in dogs[4]. Oral famotidine administration results in a diminished effect on intragastric pH in healthy cats when given twice daily every day[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.96mL

0.59mL

0.30mL

14.82mL

2.96mL

1.48mL

29.63mL

5.93mL

2.96mL
参考文献

[1]Inan A, Sen M, et al. Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats. Clinics (Sao Paulo). 2009;64(6):567-70.

[2]Balcomb CC, Heller MC, Chigerwe M, Knych HK, Meyer AM. Pharmacokinetics and efficacy of intravenous famotidine in adult cattle. J Vet Intern Med. 2018 May;32(3):1283-1289

[3]Tolbert MK, Graham A, Odunayo A, Price J, Steiner JM, Newkirk K, Hecht S. Repeated Famotidine Administration Results in a Diminished Effect on Intragastric pH in Dogs. J Vet Intern Med. 2017 Jan;31(1):117-123

[4]Hedges K, Odunayo A, Price JM, Hecht S, Tolbert MK. Evaluation of the effect of a famotidine continuous rate infusion on intragastric pH in healthy dogs. J Vet Intern Med. 2019 Sep;33(5):1988-1994

[5]Golly E, Odunayo A, Daves M, Vose J, Price J, Hecht S, Steiner JM, Hillsman S, Tolbert MK. The frequency of oral famotidine administration influences its effect on gastric pH in cats over time. J Vet Intern Med. 2019 Mar;33(2):544-550