产品说明书

UK-383367

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Chemical Structure| 348622-88-8 同义名 : -
CAS号 : 348622-88-8
货号 : A699713
分子式 : C15H24N4O4
纯度 : 99%+
分子量 : 324.375
MDL号 : MFCD19690945
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 65 mg/mL(200.39 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Procollagen C Proteinase

    Procollagen C proteinase, IC50:44 nM
描述 UK-383367 is a procollagen C-proteinase inhibitor with IC50 of 44 nM, has excellent selectivity over MMPs.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.08mL

0.62mL

0.31mL

15.41mL

3.08mL

1.54mL

30.83mL

6.17mL

3.08mL
参考文献

[1]Bailey S, Fish PV, et al. Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6562-7.

[2]Fish PV, Allan GA, et al. Potent and selective nonpeptidic inhibitors of procollagen C-proteinase. J Med Chem. 2007 Jul 26;50(15):3442-56.