生物活性 | |||
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描述 | Latanoprost (PHXA41) is a prostaglandin F2α analogue utilized in glaucoma research. It can penetrate the cornea and is metabolized by esterase into latanoprost acid. Latanoprost acid acts as an F-prostaglandin (FP) receptor agonist, effectively lowering intraocular pressure (IOP) by enhancing aqueous humor outflow through the uvea[1]. | ||
作用机制 | Latanoprost is a PGF2α analogue.[3] |
临床研究 | |||||
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT00442312 | Glaucoma | Phase 4 | Unknown | - | Taiwan ... 展开 >> Allergan Taipei, Taiwan 收起 << |
NCT03762369 | Primary Open-angle Glaucoma ... 展开 >> Ocular Hypertension 收起 << | Phase 3 | Not yet recruiting | May 30, 2022 | Korea, Republic of ... 展开 >> Seoul National University Hosipital Seoul, Jongno, Korea, Republic of 收起 << |
NCT01433900 | Glaucoma | Phase 3 | Unknown | June 2014 | Italy ... 展开 >> San Paolo Hospital Recruiting Milano, Italy, 20142 Principal Investigator: Luca Rossetti, MD Principal Investigator: Paolo Fogagnolo, MD 收起 << |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.31mL 0.46mL 0.23mL |
11.56mL 2.31mL 1.16mL |
23.12mL 4.62mL 2.31mL |
参考文献 |
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